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REVIEW article
Front. Bioeng. Biotechnol.
Sec. Biomaterials
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1566743
This article is part of the Research TopicBiodegradable Polymers for Biomedical Applications - Volume IVView all articles
Advancements in Insulin Delivery: The Potential of Natural Polymers for Improved Diabetes Management
Provisionally accepted
Mohammed Ghazwani1*
Umme Hani1Ashishkumar Kyada2Suhas Ballal3Bahjat Saeed Issa4Munthar Kadhim Abosaoda5Abhayveer Singh6A Sabarivani7Subhashree Ray8- 1King Khalid University, Abha, Saudi Arabia
- 2Marwadi University, Rajkot, Gujarat, India
- 3Jain University, Bengaluru, Karnataka, India
- 4AlNoor University College, Mosul, Nineveh, Iraq
- 5Islamic University of Najaf, Najaf, Iraq
- 6Chitkara Institute of Engineering & Technology, Chitkara University, Punjab, Punjab, India
- 7Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, India
- 8Siksha O Anusandhan University, Bhubaneswar, Odisha, India
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Diabetes is a growing global health issue, with millions of people affected by the condition. While insulin therapy is vital for managing both Type 1 and Type 2 diabetes, traditional methods such as subcutaneous injections have notable drawbacks, including pain, discomfort, and difficulty in maintaining stable blood sugar levels. To improve insulin delivery, research is increasingly focused on the use of natural polymers-substances derived from plants, animals, and microorganisms. These polymers, including materials like alginate, chitosan, and hyaluronic acid, have promising properties such as biocompatibility, biodegradability, and the ability to provide controlled, sustained insulin release. By encapsulating insulin in polymers, it is protected from degradation and released in a manner that more closely mirrors the body's natural insulin production. Furthermore, the development of non-invasive delivery methods, such as oral and transdermal systems, is gaining momentum, offering the potential for more patient-friendly treatment options. This review discusses the role of natural polymers in insulin delivery, examining their mechanisms, types, and current research efforts. It also addresses the challenges that remain in advancing these technologies into practical clinical use, aiming to provide more efficient, comfortable, and effective solutions for diabetes management.
Keywords: insulin delivery, Natural Polymers, diabetes management, Controlled Release, oral delivery
Received: 25 Jan 2025; Accepted: 16 Apr 2025.
Copyright: © 2025 Ghazwani, Hani, Kyada, Ballal, Issa, Abosaoda, Singh, Sabarivani and Ray. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Mohammed Ghazwani, King Khalid University, Abha, Saudi Arabia
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.