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ORIGINAL RESEARCH article

Front. Bioeng. Biotechnol.
Sec. Biomechanics
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1559963
This article is part of the Research Topic Diagnostic and Predictive Roles of Computational Cardiovascular Hemodynamics in the Management of Cardiovascular Diseases View all 8 articles

Morphological analysis of myocardial bridging leading to myocardial ischemia: myocardial coronary coupling

Provisionally accepted
Dongliang Zhao Dongliang Zhao 1,2*Guanghao Yu Guanghao Yu 3Zhaokai Ming Zhaokai Ming 4Dan Qiao Dan Qiao 5Zhiguo Cheng Zhiguo Cheng 6Liandi Li Liandi Li 7Wei Guo Wei Guo 3Xiaoqiang Ye Xiaoqiang Ye 8Jian Xing Jian Xing 3Wei Ma Wei Ma 3Guangxin Chen Guangxin Chen 3Mingming Ren Mingming Ren 8Wenchang Tan Wenchang Tan 2
  • 1 peking university, Shenzhen Bay Laboratory, Shenzhen, China
  • 2 Shenzhen Graduate School, Peking University, Shenzhen, Guangdong, China
  • 3 Mudanjiang Medical University, Mudanjiang, China
  • 4 The First Hospital of Qiqihar, Qiqihar, China
  • 5 Sir Run Run Shaw Hospital, hangzhou, China
  • 6 Shenzhen Bay Laboratory, Shenzhen, Guangdong, China
  • 7 Second Affiliated Hospital of Mudanjiang Medical University, Mudanjiang, China
  • 8 Shenzhen Hospital, Peking University, Shenzhen, Beijing Municipality, China

The final, formatted version of the article will be published soon.

    Myocardial bridge (MB) is a segment of an otherwise extramyocardial blood vessel that traverses the myocardium. This congenital condition typically lacks obvious clinical manifestations during adolescence. However, as individuals age, the accumulated myocardial pressure on the coronary arteries can lead to non-obstructive coronary ischemia, angina pectoris, and even heart failure. Early diagnosis is crucial for assessing the risk of cardiovascular events. This study performed a morphological analysis of MB in 75 patients using dual-source Computed Tomographic Angiography (CTA). Through geometric three-dimensional reconstruction, measurements and statistical analyses were conducted on muscle bridge length, depth, length-to-depth ratio, cross-sectional area, and coronary artery curvature. This study explores the morphological differences among normal individuals, those with superficial MB, and those with deep MB during diastole and systole under varying conditions of myocardial coronary coupling. The study found that the compression degree is greatest in the deep MB group, with the average compression level being approximately 17 times that of normal individuals and about 4.6 times that of patients with superficial MB. The differences in the average cross-sectional area are more significant than those in the minimum cross-sectional area.The depth of the MB is more closely related to the degree of compression, suggesting that clinical intervention and attention should be focused on deep MBs.

    Keywords: Bridging, Myocardial Ischemia, morphological analysis, Dual source CT, myocardial coronary coupling

    Received: 13 Jan 2025; Accepted: 07 Feb 2025.

    Copyright: © 2025 Zhao, Yu, Ming, Qiao, Cheng, Li, Guo, Ye, Xing, Ma, Chen, Ren and Tan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Dongliang Zhao, peking university, Shenzhen Bay Laboratory, Shenzhen, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.