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REVIEW article
Front. Bioeng. Biotechnol.
Sec. Biomaterials
Volume 13 - 2025 |
doi: 10.3389/fbioe.2025.1548675
This article is part of the Research Topic Translational development of tailored implants based on new processing approaches and surface modifications for tissue regeneration View all articles
The rational design, biofunctionalization and biological properties of orthopedic porous titanium implants: A review
Provisionally accepted- 1 Wuxi People's Hospital, Wuxi, China
- 2 Nanjing Medical University, Nanjing, Jiangsu Province, China
- 3 Wuxi Xishan NJU Institute of Applied Biotechnology, Wuxi, China
The rational design, biofunctionalization and biological properties of orthopedic porous titanium implants: A review Porous titanium implants are becoming an important tool in orthopedic clinical applications. This review provides a comprehensive survey of recent advances in porous titanium implants for orthopedic use. First, the review briefly describes the characteristics of bone and the design requirements of orthopedic implants. Subsequently, the pore size and structural design of porous titanium alloy materials are presented, then we introduce the application of porous titanium alloy implants in orthopedic clinical practice, including spine surgery, joint surgery, and the treatment of bone tumors. Following that, we describe the surface modifications applied to porous titanium implants to obtain better biological functions. Finally, we discuss incorporating environmental responsive mechanisms into porous titanium alloy materials to achieve additional functionalities.
Keywords: Additive manufacturing, 3D printing, Orthopedic implants, Surface modification, Environment-responsive, bone tissue engineering
Received: 20 Dec 2024; Accepted: 06 Feb 2025.
Copyright: © 2025 Guo, Ding, Cheng, Zheng, Fang and Feng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Chunliang Guo, Wuxi People's Hospital, Wuxi, China
Tao Ding, Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China
Yuan Cheng, Wuxi Xishan NJU Institute of Applied Biotechnology, Wuxi, China
Jianqing Zheng, Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China
Xiule Fang, Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China
Zhiyun Feng, Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China
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