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REVIEW article
Front. Bioeng. Biotechnol.
Sec. Synthetic Biology
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1519764
This article is part of the Research TopicSynthetic Biology Approaches for Biocatalytic Production of Value-Added ChemicalsView all articles
Expanding the application of tyrosine: Engineering microbes for the production of tyrosine and its derivatives
Provisionally accepted- 1Zhejiang University of Technology, Hangzhou, China
- 2Jiangxi Agricultural University, Nanchang, Jiangxi, China
- 3East China University of Science and Technology, Shanghai, Shanghai, China
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Aromatic compounds are widely used in the fields of medicine, chemical industry, and food, with a considerable market size. Tyrosine, an aromatic amino acid, boasts not only a wide range of applications but also serves as a valuable precursor for synthesizing a diverse array of high-value aromatic compounds. Amid growing concerns over environmental and resource challenges, the adoption of green, clean, and sustainable biotechnology for producing aromatic compounds is gaining increasing recognition as a viable alternative to traditional chemical synthesis and plant extraction methods. This article provides an overview of the current status of tyrosine biomanufacturing and explores the methods for generating derivatives, including resveratrol, levodopa, p-coumaric acid, caffeic acid, zosteric acid, tyrosol, hydroxytyrosol, tanshinol, naringenin, eriodictyol, and salidroside, using tyrosine as a primary raw material. Furthermore, this review examines the current challenges and outlines future directions for microbial fermentation for the production of tyrosine and its derivatives.
Keywords: Aromatic compounds, Tyrosine, Biomanufacturing, Microbial fermentation, Metabolic engineering AAAs: Aromatic amino acids, EMP: glycolytic pathway, PEP: phosphoenolpyruvate, MOPS: 3morpholino propanesulfonic acid, L-DOPA: levodopa, MAGE: Multiplex Automated Genome Engineering, PAL: phenylalanine ammonia lyase, PAPS: 3′-phosphoadenosine 5′-phosphosulfate
Received: 30 Oct 2024; Accepted: 09 Apr 2025.
Copyright: © 2025 Jian, Fu, Zhang, Ye, Qing, Ke and Xiaohe. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Su Wei Ke, Zhejiang University of Technology, Hangzhou, China
Chu Xiaohe, Zhejiang University of Technology, Hangzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.