Skip to main content

ORIGINAL RESEARCH article

Front. Bioeng. Biotechnol.
Sec. Biomechanics
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1519608
This article is part of the Research Topic Diagnostic and Predictive Roles of Computational Cardiovascular Hemodynamics in the Management of Cardiovascular Diseases View all 7 articles

Fluid-structure interaction analysis for abdominal aortic aneurysms: the role of multi-layered tissue architecture and intraluminal thrombus

Provisionally accepted
Xinhai Yue Xinhai Yue Jiayi Huang Jiayi Huang Ju Liu Ju Liu *
  • Department of Mechanics and Aerospace Engineering, Southern University of Science and Technology, Shenzhen, China

The final, formatted version of the article will be published soon.

    Abdominal aortic aneurysm (AAA) is a life-threatening disease marked by localized dilatations of the infrarenal aortic wall. Although clinical guidelines often regard the aneurysm diameter as an indicator for surgical intervention, this metric alone may not reliably predict rupture risks, underscoring the need for detailed biomechanical analyses. In this study, we investigate the effects of the multi-layered tissue architecture and the intraluminal thrombus (ILT) on the wall stress distribution of AAA. Using fluidstructure interaction, we analyze the biomechanical responses of fusiform and saccular AAAs under three conditions: without ILT, with ILT but no tissue degradation, and with both ILT and tissue degradation. The results show that the media is the primary load-bearing layer, and the multi-layered model yields a more accurate stress profile than the single-layered tissue model. The ILT substantially reduces overall stress levels in the covered tissue, although its impact on the location of peak stress varies across different scenarios. Additionally, media degradation increases the stress in the intima and adventitia, but the cushioning effect of ILT largely mitigates this impact. These findings underscore the importance of incorporating the multi-layered tissue architecture and ILT in patient-specific analyses of AAA.

    Keywords: Fluid-Structure Interaction, Abdominal Aortic Aneurysm, Intraluminal thrombus, Multi-layered anisotropic tissue model, Patient-Specific Modeling

    Received: 30 Oct 2024; Accepted: 03 Jan 2025.

    Copyright: © 2025 Yue, Huang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ju Liu, Department of Mechanics and Aerospace Engineering, Southern University of Science and Technology, Shenzhen, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.