94% of researchers rate our articles as excellent or good
Learn more about the work of our research integrity team to safeguard the quality of each article we publish.
Find out more
REVIEW article
Front. Bioeng. Biotechnol.
Sec. Tissue Engineering and Regenerative Medicine
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1514318
Crafting the Future of Bone Regeneration: The Promise of Supramolecular Peptide Nanofiber Hydrogels
Provisionally accepted- 1 Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China
- 2 Eye Center, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China
- 3 Center of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan, Hebei Province, China
Bone tissue engineering has rapidly emerged as an ideal strategy to replace autologous bone grafts, establishing a comprehensive system centered on biomaterial scaffolds, seeding cells, bioactive factors, and biophysical stimulation, thus paving the way for new horizons in surgical bone regeneration. However, the scarcity of suitable materials poses a significant challenge in replicating the intricate multi-layered structure of natural bone tissue. Supramolecular peptide nanofiber hydrogels (SPNHs) have shown tremendous potential as novel biomaterials due to their excellent biocompatibility, biodegradability, tunable mechanical properties, and multifunctionality. Various supramolecular peptides can assemble into nanofiber hydrogels, while bioactive sequences and factors can be embedded through physical adsorption or covalent binding, endowing the hydrogels with diverse biochemical properties. Finally, this review explored the future challenges and prospects of SPNHs in bone tissue engineering, with the aim of providing insights for further advancements in this field.
Keywords: hydrogel composites, Bone tissue regeneration, Bioactive peptides, Scaffold materials, Advanced biomaterials
Received: 22 Oct 2024; Accepted: 24 Feb 2025.
Copyright: © 2025 Wan, Yao, Pan, Xiang, Ye and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qingsong Ye, Center of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan, Hebei Province, China
Fei Wu, Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.