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ORIGINAL RESEARCH article
Front. Bioeng. Biotechnol.
Sec. Biosafety and Biosecurity
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1442651
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In order to understand the laboratory biosafety status of Jiaxing from 2021 to 2023, before and after the end of the COVID-19 strict control strategy, this study used Zhejiang local standard DB33/T 2540 to conduct biosafety quality control inspection and risk identification, and used Chinese industry standard RB/T 040 for risk analysis and assessment. The results showed that the major problems in biosafety management were from organization management, laboratory housekeeping, material and label management, and facilities and equipment, accounting for 39.76%, 28.97% and 14.69% respectively. Statistical analysis showed that the significant improvement of laboratory filing requirements ( χ ² = 5.84, P = 0.016) was the main reason for the decrease of organization management problems ( χ ² = 5.007, P = 0.025). The problems of laboratory housekeeping, experimental material and safety label management had become increasingly prominent (χ² = 6.192, P = 0.013), especially the nonstandard use of biosafety label ( χ ² = 5.218, P = 0.022). Assessment results showed that all found problems as identified risk factors in the past 3 years were determined at the level of medium or low. These suggested that in 2021-2023, the overall laboratory biosafety risk level in Jiaxing was controllable and acceptable, and the organization management had been improved greatly. At the same time, the management of laboratory housekeeping, materials and labels, especially the use of biosafety labels, had become increasingly prominent and need to be standardized and strengthened.
Keywords: biosafety, biosecurity, Risk Assessment, laboratory, Quality control, Public Health
Received: 02 Jun 2024; Accepted: 27 Mar 2025.
Copyright: © 2025 Yong, Li, Xu, Gao, Lv, Li, Xiang, He, Ren, Zhu and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Guoying Zhu, Jiaxing Center for Disease Control and Prevention, Jiaxing, China
Zhongwen Chen, Jiaxing Center for Disease Control and Prevention, Jiaxing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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