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ORIGINAL RESEARCH article

Front. Bioeng. Biotechnol.
Sec. Biomaterials
Volume 13 - 2025 | doi: 10.3389/fbioe.2025.1352895

Short-term Follow-up of Antibiotic-loaded Calcium Sulfate in Treating Chronic Periprosthetic Joint Infection During Two-stage Revision

Provisionally accepted
Jun Tan Jun Tan 1,2*Lijuan Zhan Lijuan Zhan 3Mingkui Shen Mingkui Shen 2Zhongxin Tang Zhongxin Tang 2Haijun Ma Haijun Ma 2Lingxiao Wu Lingxiao Wu 4Jianzhong Xu Jianzhong Xu 4
  • 1 Department of Orthopaedic Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
  • 2 Department of Orthopedic Surgery, The Third People,s Hospital of Henan Province, zhengzhou, China
  • 3 Department of Neurology, People,s Hospital of Zhengzhou, zhengzhou, China
  • 4 Department of Orthopaedics, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China

The final, formatted version of the article will be published soon.

    Background: Periprosthetic joint infection (PJI) is a significant and challenging complication following total knee arthroplasty (TKA). This study aimed to evaluate the efficacy and safety of treating chronic knee PJI with and without antibiotic-loaded calcium sulfate during two-stage revision surgery.Methods: This retrospective study analyzed 94 patients with TKA infections who underwent twostage revision between May 2017 and January 2022 at the First Affiliated Hospital of Zhengzhou University. Key outcomes assessed included infection recurrence rates, postoperative range of motion (ROM), Knee Society Score (KSS), Hospital for Special Surgery (HSS) scores, hematological parameters, and complication rates during the follow-up period.The demographic characteristics of the two groups showed no significant differences. The infection control rate was significantly higher in the calcium sulfate group (95.7%) compared to the matched control group (80.9%) (P<0.05). Both groups demonstrated statistically significant improvements in ROM, HSS, and KSS scores compared to preoperative values (P<0.05). However, intergroup differences in these outcomes were not statistically significant (P>0.05). Additionally, there was no significant difference in postoperative complication rates between the two groups.The use of antibiotic-loaded calcium sulfate in two-stage revision surgery for chronic knee PJI ensures sustained local antibiotic release at high concentrations, leading to rapid reduction in inflammatory markers, effective infection control, and a low complication rate. This approach is a safe and effective treatment for chronic knee PJI.

    Keywords: Calcium Sulfate, antibiotic, periprosthetic joint infection, Two-stage revision, Arthroplasty Antibiotic-loaded Calcium Sulfate For PJI

    Received: 13 Dec 2023; Accepted: 10 Jan 2025.

    Copyright: © 2025 Tan, Zhan, Shen, Tang, Ma, Wu and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jun Tan, Department of Orthopaedic Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.