Skip to main content

ORIGINAL RESEARCH article

Front. Bioeng. Biotechnol.
Sec. Biomaterials
Volume 12 - 2024 | doi: 10.3389/fbioe.2024.1525644
This article is part of the Research Topic Advances in Glycopeptide Hydrogel for Tissue Engineering View all articles

An injectable, self-healing, anti-infective, and anti-inflammatory novel glycyrrhizic acid hydrogel for promoting acute wound healing and regeneration

Provisionally accepted
Qiyou Guo Qiyou Guo 1Ruojing Li Ruojing Li 1Yeying Zhao Yeying Zhao 2Huibo Wang Huibo Wang 1Wenqiang Luo Wenqiang Luo 1Zhenlu Li Zhenlu Li 1*Peige Wang Peige Wang 1*
  • 1 Department of Emergency Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China
  • 2 Zhejiang Zhuji People's Hospital, Zhuji, China

The final, formatted version of the article will be published soon.

    Bacterial infection of acute wounds, a complex wound microenvironment, and persistent inflammation can lead to delayed wound healing and scar formation, thus disrupting the normal function and appearance of skin tissue, which is one of the most difficult clinical problems.Hydrogels can mimic the extracellular matrix and show great potential in life science fields such as tissue regeneration, wound repair, and controlled drug release. In this study, a composite hydrogel scaffold was constructed by the reaction of oxidized glycyrrhizic acid with the Schiff base of carboxymethyl chitosan. Studies have shown that this hydrogel has good injectability, biocompatibility, and antibacterial activity, improves the wound microenvironment, which in turn influences the polarization of macrophages from M1 to M2 types, reduces inflammatory responses, promotes angiogenesis and granulation tissue regeneration, and accelerates wound healing. The results indicate that the new glycyrrhizic acid hydrogel will become a new strategy for the treatment of acute wounds in future clinical applications.

    Keywords: Glycyrrhizic Acid, Hydrogels, Wound dressings, Acute wounds, wound repair

    Received: 10 Nov 2024; Accepted: 23 Dec 2024.

    Copyright: © 2024 Guo, Li, Zhao, Wang, Luo, Li and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zhenlu Li, Department of Emergency Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong Province, China
    Peige Wang, Department of Emergency Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.