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REVIEW article

Front. Bioeng. Biotechnol.
Sec. Tissue Engineering and Regenerative Medicine
Volume 12 - 2024 | doi: 10.3389/fbioe.2024.1523225
This article is part of the Research Topic Tissue Engineering Strategies and Biomaterials in Oral and Maxillofacial Hard Tissue Injury Repair View all 5 articles

Using platelet concentrates to treat maxillofacial tissue lesions

Provisionally accepted
Ruijia Liu Ruijia Liu 1*Siqi Chen Siqi Chen 1*Peng Wang Peng Wang 1,2*Ruiye Bi Ruiye Bi 1,2*
  • 1 State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, Sichuan Province, China
  • 2 Department of Orthognathic and Arthrical Surgery, West China School of Stomatology, Sichuan University, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    Objectives: Platelet concentrates (PCs), which are blood products that are abundant in platelets and growth factors, have become pivotal in treating maxillofacial tissue lesions due to their capacity for promoting bone and soft tissue recovery. This review will provide some recent progress of the use of platelet concentrates to treat lesions on maxillofacial tissues. Subjects: We reviewed the mechanisms by which PCs promote wound healing and tissue recovery and summarized the application of PCs in the treatment of lesions on maxillofacial tissues, including medication-related osteonecrosis of the jaw, postextraction wound healing, implant surgery, temporomandibular joint diseases, and periodontal tissue restoration. Results: PC promotes the attachment and proliferation of osteoblasts, as well as the synthesis and deposition of collagen fibers by stimulating the AFK pathway and releasing growth factors and cytokines, such as secreting GFs, VEGF, TGF-β, etc. They also induce angiogenesis, inhibit bone resorption, promote the healing of soft tissues, relieve symptoms, reduce postoperative complications and maintain implant stability. Conclusions: PCs may be used as an adjuvant therapy in the treatment of lesions on maxillofacial tissues. However, more studies should refine the preparation and treatment methods for platelet concentrates and establish a foundation for their extensive application.

    Keywords: Platelet concentrates, Platelet-Rich Plasma, Platelet-rich fibrin, Bone Regeneration, Soft tissue regeneration

    Received: 05 Nov 2024; Accepted: 20 Dec 2024.

    Copyright: © 2024 Liu, Chen, Wang and Bi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Ruijia Liu, State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, 610041, Sichuan Province, China
    Siqi Chen, State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, 610041, Sichuan Province, China
    Peng Wang, State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, 610041, Sichuan Province, China
    Ruiye Bi, State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, 610041, Sichuan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.