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ORIGINAL RESEARCH article

Front. Bioeng. Biotechnol.
Sec. Tissue Engineering and Regenerative Medicine
Volume 12 - 2024 | doi: 10.3389/fbioe.2024.1495810

Effects of polylactic acid scaffolds with various orientations and diameters on osteogenesis and angiogenesis

Provisionally accepted
云容 徐 云容 徐 1代远 唐 代远 唐 1*振平 肖 振平 肖 1*在田 黄 在田 黄 1*恒瑞 张 恒瑞 张 1*梓闻 唐 梓闻 唐 2*飞 何 飞 何 1*
  • 1 Qujing Affiliated Hospital of Kunming Medical University, Qujing, China
  • 2 The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China

The final, formatted version of the article will be published soon.

    Researchers in the field of regenerative medicine have consistently focused on the biomimetic design of engineered bone materials on the basis of the microstructure of natural bone tissue. Additionally, the effects of the micromorphological characteristics of these materials on angiogenesis have garnered increasing attention. In vitro, the orientation and diameter of scaffold materials can exert different effects on osteogenesis and vascularisation. However, more comprehensive investigations, including in vivo studies, are required to confirm the results observed in vitro.Accordingly, in the present study, fibre scaffolds with various orientations and diameters were prepared by electrospinning with polylactic acid. The effects of the micromorphological characteristics of these scaffolds with different orientations and diameters on osteogenesis and vascularisation were systematically studied via in vivo experiments. The scaffolds with aligned micromorphological features positively affected osteogenesis and vascularisation, which indicated that such characteristics could be considered crucial factors when designing materials for bone repair.

    Keywords: micromorphology, Polylactic Acid, Orientation, diameter, Osteogenesis, Vascular Generation

    Received: 13 Sep 2024; Accepted: 18 Dec 2024.

    Copyright: © 2024 徐, 唐, 肖, 黄, 张, 唐 and 何. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    代远 唐, Qujing Affiliated Hospital of Kunming Medical University, Qujing, China
    振平 肖, Qujing Affiliated Hospital of Kunming Medical University, Qujing, China
    在田 黄, Qujing Affiliated Hospital of Kunming Medical University, Qujing, China
    恒瑞 张, Qujing Affiliated Hospital of Kunming Medical University, Qujing, China
    梓闻 唐, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, China
    飞 何, Qujing Affiliated Hospital of Kunming Medical University, Qujing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.