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ORIGINAL RESEARCH article

Front. Bioeng. Biotechnol.
Sec. Nanobiotechnology
Volume 12 - 2024 | doi: 10.3389/fbioe.2024.1485549
This article is part of the Research Topic Nanotechnology-Based Delivery Systems for Cancer Treatment View all articles

Manganese-pyrochloric acid photosensitizer nanocomplexes against osteosarcoma: Achieving both high activatability and high effectiveness

Provisionally accepted
Xuran Zhang Xuran Zhang 1Jian Wang Jian Wang 2Qun Feng Qun Feng 3Li Lei Li Lei 1Zhiyong Zhu Zhiyong Zhu 3*
  • 1 Department of Orthopedics,Fuxin Center Hospital, Fuxin, Liaoning, China
  • 2 Department of Orthopedics, First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning Province, China
  • 3 The People's Hospital of Liaoning Province, Shenyang, Liaoning Province, China

The final, formatted version of the article will be published soon.

    The application of photodynamic therapy (PDT) is limited by unsatisfactory therapeutic efficacy and dose-dependent phototoxicity in clinic. Intravenous nano-drug delivery systems (NDDSs) hold promise for enhancing the delivery efficiency of photosensitive drugs. Nevertheless, nanocarrier-based NDDSs often result in aggregation-caused quenching effect of photosensitive drugs, failing to site-specific activation. In this study, we exploited the manganese (Mn 2+ )-pyrochloric acid (PPa) nanocomplexes with both high activatability and high effectiveness, which is coordinated using the photosensitizer PPa and metal Mn ion for the treatment of osteosarcoma. The precisely nanocomplexes could be co-assembled in water, stably co-deliver and tumor-specific release of Mn 2+ and PPa, enabling fluorescence recovery. Following laser irradiation, the activated PPa significantly exerts the primary cancer cells-killing effects. Notably, manganese ions Mn 2+ , activating the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, is observed as a result of maturation of dendritic cells (DCs), augmenting CD8 + -mediated antitumor immune response. Taken together, this study advances on-demand activation of photosensitive drugs and photodynamic immunotherapy toward clinical applicability.

    Keywords: Photodynamic therapy (PDT), nano-drug delivery systems (NDDSs), manganese (Mn2+)-pyrochloric acid (PPa) nanocomplexes, both high activatability and high effectiveness, Osteosarcoma

    Received: 24 Aug 2024; Accepted: 11 Nov 2024.

    Copyright: © 2024 Zhang, Wang, Feng, Lei and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zhiyong Zhu, The People's Hospital of Liaoning Province, Shenyang, Liaoning Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.