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ORIGINAL RESEARCH article

Front. Bioeng. Biotechnol.
Sec. Biomaterials
Volume 12 - 2024 | doi: 10.3389/fbioe.2024.1483547

Advances in 3D printing technology for preparing bone tissue engineering scaffolds from biodegradable materials

Provisionally accepted
Yanan Sun Yanan Sun 1*Zhen Wang Zhen Wang 2
  • 1 Yanshan University, Qinhuangdao, China
  • 2 Shandong University of Science and Technology, Qingdao, Shandong Province, China

The final, formatted version of the article will be published soon.

    Bone tissue engineering (BTE) offers an effective repair solution by promoting bone tissue regeneration through the implantation of osteogenic cells or stem cells into biocompatible and biodegradable scaffolds. 3D bioprinting technology, using computer-generated 3D models as "blueprints" and assembling specialized "bio-inks," has been widely applied in the fabrication of tissue engineering scaffolds. This paper reviews the characteristics of scaffold materials for bone tissue engineering and compares the advantages and disadvantages of various materials used in 3D printing.Bioceramics exhibit excellent biocompatibility but are highly brittle; metal materials offer high strength but may trigger chronic inflammation; natural polymers have superior biocompatibility but poor mechanical properties; and synthetic polymers are highly tunable but may produce acidic byproducts during degradation. The paper summarizes recent applications of 3D bioprinting in bone tissue engineering, exploring the potential of combining 3D bioprinting technology with composite materials to enhance scaffold biocompatibility and mechanical performance. This opens new technological pathways for the personalized design of scaffolds in clinical applications. The study provides a unique perspective and theoretical support for advancing 3D bioprinting technology in bone regeneration and looks ahead to future developments in bone tissue engineering materials and 3D bioprinting.

    Keywords: bone tissue engineering, biodegradable materials, Bone Regeneration, 3D bioprinting technology, Scaffold fabrication

    Received: 20 Aug 2024; Accepted: 29 Oct 2024.

    Copyright: © 2024 Sun and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yanan Sun, Yanshan University, Qinhuangdao, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.