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ORIGINAL RESEARCH article

Front. Bioeng. Biotechnol.
Sec. Biomaterials
Volume 12 - 2024 | doi: 10.3389/fbioe.2024.1480573
This article is part of the Research Topic Environmentally-Responsive Biomaterials for Major Diseases Treatment View all 7 articles

Nanodiamond-Mediated Delivery of microRNA-7 for the Neuroprotection of Dopaminergic Neurons

Provisionally accepted
Yuping Han Yuping Han Yue Yao Yue Yao *Xinyi Wen Xinyi Wen *Hao Wang Hao Wang Shurong Li Shurong Li *Bingyin Su Bingyin Su *
  • Chengdu Medical College, Chengdu, China

The final, formatted version of the article will be published soon.

    Parkinson's disease (PD) is a neurodegenerative disorder characterized by the gradual loss of dopaminergic neurons in the substantia nigra and the accumulation of α-synuclein aggregates known as Lewy bodies. MicroRNA-7 (miR-7) targets the gene SNCA, which encodes α-synuclein, reducing its expression and alleviating neuronal damage in PD. Regulating the post-transcriptional levels of αsynuclein through miR-7 effectively inhibits its production. Herein, we use nanodiamonds as carriers to deliver miR-7 (N-7), which can effectively protect dopaminergic neurons. Dopaminergic neurons efficiently take up N-7 and express miR-7. N-7 inhibits the expression of α-synuclein, reduces oxidative stress and restores dopamine levels effectively. These findings suggest that nanocomposites have significant potential in treating PD.

    Keywords: Nanodiamonds, microRNA-7, Parkinson's disease, Dopaminergic Neurons, Oxidative Stress

    Received: 14 Aug 2024; Accepted: 20 Dec 2024.

    Copyright: © 2024 Han, Yao, Wen, Wang, Li and Su. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yue Yao, Chengdu Medical College, Chengdu, China
    Xinyi Wen, Chengdu Medical College, Chengdu, China
    Shurong Li, Chengdu Medical College, Chengdu, China
    Bingyin Su, Chengdu Medical College, Chengdu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.