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ORIGINAL RESEARCH article
Front. Bioeng. Biotechnol.
Sec. Biosensors and Biomolecular Electronics
Volume 12 - 2024 |
doi: 10.3389/fbioe.2024.1477886
This article is part of the Research Topic The Application of Artificial Intelligence in the Design, Development and Manufacturing of Biosensors and Devices View all articles
Adaptive Control of Airway Pressure During the Expectoration Process in a Cough Assist System
Provisionally accepted- 1 School of Automation Science and Electrical Engineering, Beihang University, Beijing, Beijing, China
- 2 Beihang University, Beijing, China
- 3 Jingdezhen Ceramic University, Jindezhen, China
- 4 First Affiliated Hospital of Chinese PLA General Hospital, Beijing, Beijing Municipality, China
Existing Mechanical Insufflation-Exsufflation (MI-E) devices often overlook the impact of cough airflow pressure on mucus clearance, particularly lacking in control over airway pressure during the expiratory phase, which can lead to airway collapse and other types of airway damage. This study optimizes the design of cough assist system and explores the effectiveness of PID and adaptive control methods in regulating airway pressure. The adaptive control method compensates for hose pressure drop by online estimation of the ventilatory hose characteristics. It achieves precise tracking of target pressure and ensures the generation of peak flow rates effective for mucus clearance, even in the absence of known patient lung physiological states and unknown hose leakage parameters. Through a series of comparative experiments, this paper confirms the significant advantages of adaptive control in reducing oscillations and overshoot, capable of more stable and precise airway pressure adjustments. This improved control strategy not only enhances clinical safety but also significantly improves therapeutic outcomes and reduces the risk of complications. The findings indicate that the revamped cough assist system, employing an adaptive control strategy, can effectively prevent airway damage during assisted coughing, offering a safer and more effective sputum clearance solution for critically ill patients with expectoration disorders.
Keywords: Cough assist, MI-E, Airway pressure, Adaptive control, clinical safety
Received: 08 Aug 2024; Accepted: 23 Aug 2024.
Copyright: © 2024 Lu, Wang, Shen and Fei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yixuan Wang, Beihang University, Beijing, China
Guolang Shen, Jingdezhen Ceramic University, Jindezhen, China
Xie Fei, First Affiliated Hospital of Chinese PLA General Hospital, Beijing, 100853, Beijing Municipality, China
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