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REVIEW article

Front. Bioeng. Biotechnol.
Sec. Tissue Engineering and Regenerative Medicine
Volume 12 - 2024 | doi: 10.3389/fbioe.2024.1476510

Effective and new technologies in kidney tissue engineering

Provisionally accepted
Hossein Rayat Pisheh Hossein Rayat Pisheh Mobin Haghdel Mobin Haghdel *Mahboube Jahangir Mahboube Jahangir Monireh Sadat Hoseinian Monireh Sadat Hoseinian Shaghayegh Rostami Yasuji Shaghayegh Rostami Yasuji Ali Sarhadi Roodbari Ali Sarhadi Roodbari
  • School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran

The final, formatted version of the article will be published soon.

    Kidney disease encompasses a wide spectrum of conditions, ranging from simple infections to chronic kidney disease. When the kidneys are unable to filter blood and remove waste products, these abnormalities can lead to kidney failure. In severe cases of kidney failure, kidney transplantation is considered the only definitive treatment. Worldwide, the World Health Organization (WHO) repeatedly emphasizes the importance of organ donation and increasing transplantation rates. Many countries implement national programs to promote the culture of organ donation and improve patient access to kidney transplantation. The extent to which this procedure is performed varies across countries and is influenced by several factors, including the volume of organ donation, medical infrastructure, access to technology and health policies. However, a kidney transplant comes with challenges and problems that impact its success. Kidney tissue engineering is a new approach that shows promise for repairing and replacing damaged kidney tissue. This article reviews recent advances in kidney tissue engineering, focusing on engineered structures such as hydrogels, electrospinning, 3D bioprinting, and microfluidic systems. By mimicking the extracellular environment of the kidney, these structures provide suitable conditions for the growth and development of kidney cells. The role of these structures in the formation of blood vessels, the mimicry of kidney functions and the challenges in this field were also discussed. The results of this study show that kidney tissue engineering has high potential for treating kidney diseases and reducing the need for kidney transplantation. However, to achieve clinical application of this technology, further research is required to improve the biocompatibility, vascularization and long-term performance of engineered tissues.

    Keywords: Tissue Engineering, Scaffold, 3D bioprinting, Microfluidic systems, Kidney cells, Kidney Diseases

    Received: 05 Aug 2024; Accepted: 03 Oct 2024.

    Copyright: © 2024 Rayat Pisheh, Haghdel, Jahangir, Hoseinian, Rostami Yasuji and Sarhadi Roodbari. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Mobin Haghdel, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.