AUTHOR=Dean Jillian , Hoch Cosima , Wollenberg Barbara , Navidzadeh Justin , Maheta Bhagvat , Mandava Anisha , Knoedler Samuel , Sherwani Khalil , Baecher Helena , Schmitz Alina , Alfertshofer Michael , Heiland Max , Kreutzer Kilian , Koerdt Steffen , Knoedler Leonard 

TITLE=Advancements in bioengineered and autologous skin grafting techniques for skin reconstruction: a comprehensive review

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=Volume 12 - 2024

YEAR=2025

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2024.1461328

DOI=10.3389/fbioe.2024.1461328

ISSN=2296-4185

ABSTRACT=The reconstruction of complex skin defects challenges clinical practice, with autologous skin grafts (ASGs) as the traditional choice due to their high graft take rate and patient compatibility. However, ASGs have limitations such as donor site morbidity, limited tissue availability, and the necessity for multiple surgeries in severe cases. Bioengineered skin grafts (BSGs) aim to address these drawbacks through advanced tissue engineering and biomaterial science. This study conducts a systematic review to describe the benefits and shortcomings of BSGs and ASGs across wound healing efficacy, tissue integration, immunogenicity, and functional outcomes focusing on wound re-epithelialization, graft survival, and overall aesthetic outcomes. Preliminary findings suggest ASGs show superior early results, while BSGs demonstrate comparable long-term outcomes with reduced donor site morbidity. This comparative analysis enhances understanding of bioengineered alternatives in skin reconstruction, potentially redefining best practices based on efficacy, safety, and patient-centric outcomes, highlighting the need for further innovation in bioengineered solutions.