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REVIEW article

Front. Bioeng. Biotechnol.
Sec. Biomaterials
Volume 12 - 2024 | doi: 10.3389/fbioe.2024.1458362
This article is part of the Research Topic Bioactive Materials in Biomedical Engineering: Innovations and Applications View all articles

Analysis of Urine Cell-free DNA in Bladder Cancer Diagnosis by Emerging Bioactive Technologies and Materials

Provisionally accepted
Fei-Fei Huang Fei-Fei Huang *Xiao-Fei Di Xiao-Fei Di Mo-Han Bai Mo-Han Bai
  • School of Medicine, South China University of Technology, Guangzhou, China

The final, formatted version of the article will be published soon.

    Urinary cell-free DNA (UcfDNA) is gaining recognition as an important biomarker for diagnosing bladder cancer. UcfDNA contains tumor derived DNA sequences, making it a viable candidate for non-invasive early detection, diagnosis, and surveillance of bladder cancer. The quantification and qualification of UcfDNA have demonstrated high sensitivity and specificity in the molecular characterization of bladder cancer. However, precise analysis of UcfDNA for clinical bladder cancer diagnosis remains challenging. This review summarizes the history of UcfDNA discovery, its biological properties, and the quantitative and qualitative evaluations of UcfDNA for its clinical significance and utility in bladder cancer patients, emphasizing the critical role of UcfDNA in bladder cancer diagnosis. Emerging bioactive technologies and materials currently offer promising tools for multiple UcfDNA analysis, aiming to achieve more precise and efficient capture of UcfDNA, thereby significantly enhancing diagnostic accuracy. This review also highlights breakthroughs in detection technologies and substrates with the potential to revolutionize bladder cancer diagnosis in clinic.

    Keywords: Bladder cancer, Urinary cell-free DNA, UcfDNA, Noninvasive diagnosis, molecular characterization. ** Word Count: ** 5561 ** Figures: ** 7

    Received: 02 Jul 2024; Accepted: 23 Aug 2024.

    Copyright: © 2024 Huang, Di and Bai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Fei-Fei Huang, School of Medicine, South China University of Technology, Guangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.