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MINI REVIEW article

Front. Bioeng. Biotechnol.
Sec. Biomaterials
Volume 12 - 2024 | doi: 10.3389/fbioe.2024.1454247
This article is part of the Research Topic Micro-Nano-Materials for Drug Delivery, Disease Diagnosis, and Therapeutic Treatment View all 3 articles

An Insight into Pharmaceutical Challenges with ionic liquids: Where do we stand in transdermal delivery?

Provisionally accepted
Ankit Jain Ankit Jain 1*Ashok K. Shakya Ashok K. Shakya 2Shiv K. Prajapati Shiv K. Prajapati 3Mamdouh Eldesoqui Mamdouh Eldesoqui 4Nishi Mody Nishi Mody 5Sanjay K. Jain Sanjay K. Jain 5Rajashri R. Naik Rajashri R. Naik 2Umesh K. Patil Umesh K. Patil 5
  • 1 Birla Institute of Technology and Science, Pilani, India
  • 2 Faculty of Pharmacy and Medical Sciences, Al-Ahliyya Amman University, Amman, Amman, Jordan
  • 3 Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India
  • 4 Department of Basic Medical Sciences, Faculty of Medicine, Almaarefa University, Riyadh, Saudi Arabia
  • 5 Dr. Hari Singh Gour University, Sagar, Madhya Pradesh, India

The final, formatted version of the article will be published soon.

    Ionic liquids (ILs) represent an exciting and promising solution for advancing drug delivery platforms. Their unique properties, including broad chemical diversity, adaptable structures, and exceptional thermal stability, make them ideal candidates for overcoming challenges in transdermal drug delivery. Despite encountering obstacles such as side reactions, impurity effects, biocompatibility concerns, and stability issues, ILs offer substantial potential in enhancing drug solubility, navigating physiological barriers, and improving particle stability.To propel the use of IL-based drug delivery in pharmaceutical innovation, it is imperative to devise new strategies and solvents that can amplify drug effectiveness, facilitate drug delivery to cells at the molecular level, and ensure compatibility with the human body. This review introduces innovative methods to effectively address the challenges associated with transdermal drug delivery, presenting progressive approaches to significantly improve the efficacy of this drug delivery system.

    Keywords: Ionic Liquid, Biocompatibility, Transdermal drug delivery, Toxicity, challenges, sustainability, green cosolvents, Ionic liquids drug delivery

    Received: 24 Jun 2024; Accepted: 25 Jul 2024.

    Copyright: © 2024 Jain, Shakya, Prajapati, Eldesoqui, Mody, Jain, Naik and Patil. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ankit Jain, Birla Institute of Technology and Science, Pilani, India

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.