AUTHOR=Bardi Francesco , Gasparotti Emanuele , Vignali Emanuele , Antonuccio Maria Nicole , Storto Eleonora , Avril Stéphane , Celi Simona TITLE=A hybrid mock circulatory loop integrated with a LED-PIV system for the investigation of AAA compliant phantoms JOURNAL=Frontiers in Bioengineering and Biotechnology VOLUME=12 YEAR=2024 URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2024.1452278 DOI=10.3389/fbioe.2024.1452278 ISSN=2296-4185 ABSTRACT=Background

Cardiovascular diseases remain a leading cause of morbidity and mortality worldwide and require extensive investigation through in-vitro studies. Mock Circulatory Loops (MCLs) are advanced in-vitro platforms that accurately replicate physiological and pathological hemodynamic conditions, while also allowing for precise and patient-specific data collection. Particle Image Velocimetry (PIV) is the standard flow visualization technique for in-vitro studies, but it is costly and requires strict safety measures. High-power Light Emitting Diode illuminated PIV (LED-PIV) offers a safer and cheaper alternative.

Methods

In this study, we aim to demonstrate the feasibility of a Hybrid-MCL integrated with a LED-PIV system for the investigation of Abdominal Aortic Aneurysm (AAA) compliant phantoms. We considered two distinct AAA models, namely, an idealized model and a patient-specific one under different physiological flow and pressure conditions.

Results

The efficacy of the proposed setup for the investigation of AAA hemodynamics was confirmed by observing velocity and vorticity fields across multiple flow rate scenarios and regions of interest.

Conclusion

The findings of this study underscore the potential impact of Hybrid-MCL integrated with a LED-PIV system on enhancing the affordability, accessibility, and safety of in-vitro CVD investigations.