Skip to main content

MINI REVIEW article

Front. Bioeng. Biotechnol.
Sec. Biomaterials
Volume 12 - 2024 | doi: 10.3389/fbioe.2024.1450973
This article is part of the Research Topic Biomedical Biodegradable Matrices and Composites View all 5 articles

Novosorb® BTM-History, Production and Application in Challenging Wounds

Provisionally accepted
Rohan Rajaram Rohan Rajaram *Min Zhang Min Zhang Gehan Premaratne Gehan Premaratne Sally Ng Sally Ng
  • Austin Health, University of Melbourne, Melbourne, Australia

The final, formatted version of the article will be published soon.

    Novosorb® Biodegradable Temporizing Matrix (BTM) is an entirely synthetic dermal matrix that is gaining popularity in the management of challenging wounds. Not only does it provide a framework in which to grow an organised neodermis, it is also especially resistant to infection. Today, the matrix is available as a 2mm thick open cell polyurethane foam with a non-degrading sealing membrane. Its current form is the result of numerous in vitro and in vivo experiments that examined its shape, biodegradation, inflammatory response, and cytotoxicity. Clinical data on the use of BTM in a variety of cases is novel and presents early insights into its ability to foster wound healing where otherwise improbable. This review presents the history and development of Novosorb® BTM as well as all the currently available clinical data on its efficacy in difficult wounds such as: major burns, necrotising soft tissue infection, chronic wounds and in non graftable wound beds.

    Keywords: Biodegradable temporizing matrix (BTM), Burns, Plastic and reconstructive surgery (PRS), Necrotising fasciitis, Chronic ulcer

    Received: 18 Jun 2024; Accepted: 30 Oct 2024.

    Copyright: © 2024 Rajaram, Zhang, Premaratne and Ng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Rohan Rajaram, Austin Health, University of Melbourne, Melbourne, Australia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.