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ORIGINAL RESEARCH article

Front. Bioeng. Biotechnol.
Sec. Biomaterials
Volume 12 - 2024 | doi: 10.3389/fbioe.2024.1450626

High-Salt Diet Accelerates Skin Aging in Wistar Rats: An 8-Week Investigation of Cell Cycle Inhibitors, SASP Markers, and Oxidative Stress

Provisionally accepted
Xile Peng Xile Peng Nannan Liu Nannan Liu Baihan Zeng Baihan Zeng Yiling Bai Yiling Bai Xu Yang Xu Yang Yixiao Chen Yixiao Chen Li Chen Li Chen Lina Xia Lina Xia *
  • School of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China

The final, formatted version of the article will be published soon.

    Background: Recent studies have shown that the high salt diet (HSD) is linked to increased dermal pro-inflammatory status and reduced extracellular matrix (ECM) expression in inflamed skin of mice. Decreased ECM content is a known aging phenotype of the skin, and alterations in ECM composition and organization significantly contribute to skin aging. This study aimed to determine whether a high salt diet accelerates skin aging and to identify the time point at which this effect becomes apparent. Methods: Wistar rats were randomly divided into normal diet and high salt diet groups and fed continuously for 8 weeks. Skin samples were collected at weeks 7 and week 8. Skin pathological sections were evaluated and levels of cell cycle inhibitors, senescence-associated secretory phenotype (SASP), oxidative stress and vascular regulatory factors (VRFs) were examined. Correlation analyses were performed to reveal the effect of a high-salt diet as an extrinsic factor on skin aging and to analyse the correlation between a high-salt diet and intrinsic aging and blood flow status. Results: At week 8, HSD rats exhibited thickened epidermis, thinned dermis, and atrophied hair follicles. The expression of cell cycle inhibitors and oxidative stress levels were significantly elevated in the skin of HSD rats at both week 7 and week 8.

    Keywords: High salt diet, Skin Aging, Oxidative Stress, SASP, Cell cycle inhibitors

    Received: 20 Jun 2024; Accepted: 27 Sep 2024.

    Copyright: © 2024 Peng, Liu, Zeng, Bai, Yang, Chen, Chen and Xia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lina Xia, School of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.