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ORIGINAL RESEARCH article

Front. Bioeng. Biotechnol.
Sec. Biosensors and Biomolecular Electronics
Volume 12 - 2024 | doi: 10.3389/fbioe.2024.1450331

Radiofrequency Ablation with Sine and Square Electrical Waveforms to Enhance Ablation Range

Provisionally accepted
Dong-Sung Won Dong-Sung Won 1Jinsu An Jinsu An 2Ji Won Kim Ji Won Kim 1,3Yubeen Park Yubeen Park 1,3Sang Soo Lee Sang Soo Lee 3Hyung-Sik Kim Hyung-Sik Kim 4*Jung-Hoon Park Jung-Hoon Park 1,5*
  • 1 Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea
  • 2 Department of Biomedical Engineering, School of ICT Convergence Engineering, College of Science & Technology, Konkuk University, Chungju, Republic of Korea
  • 3 Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
  • 4 Departemnt of Mechatronics Engineering, School of ICT Convergence Engineering, College of Science & Technology, Konkuk University, Chungju, North Chungcheong, Republic of Korea
  • 5 Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

The final, formatted version of the article will be published soon.

    Radiofrequency ablation (RFA) is a local treatment modality for primary liver cancers including hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Although various input parameters of the RF generator have been adjusted to improve the ablation ranges, the limited ablation ranges remain an obstacle to RFA. This study aimed to compare the ablation ranges and efficacy of sine and square electrical waveforms in a mouse tumor model. An RF generator with an adjustable electrical waveform was developed, and its ablation range in the porcine liver was compared. For all RF parameters, the square electrical waveform ablation range was greater than that of the sine electrical waveform (all p < 0.001) in the porcine liver.The 45 BALB/c nude mice were used to evaluate the efficacy of the two electrical waveforms after the RFA. The mean tumor volume in the square group was significantly lower than that in the sine group (p < 0.001), indicating a higher survival rate (60%). The cellular coagulative necrosis, inflammatory cell infiltration, HSP 70-, TUNEL-, and TNF-α-deposition were significantly greater in square electrical waveform than in sine electrical waveform (all; p < 0.05). RFA with square electrical waveforms has therapeutic potential for tumor management with an enhanced ablation range.

    Keywords: Radiofrequency ablation, local heat treatment, Electrical waveforms, Ablation ranges, Tumor ablation

    Received: 10 Jul 2024; Accepted: 07 Aug 2024.

    Copyright: © 2024 Won, An, Kim, Park, Lee, Kim and Park. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Hyung-Sik Kim, Departemnt of Mechatronics Engineering, School of ICT Convergence Engineering, College of Science & Technology, Konkuk University, Chungju, North Chungcheong, Republic of Korea
    Jung-Hoon Park, Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.