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REVIEW article

Front. Bioeng. Biotechnol.
Sec. Biomaterials
Volume 12 - 2024 | doi: 10.3389/fbioe.2024.1448010
This article is part of the Research Topic Advanced Functional Materials for Disease Diagnosis, Drug Delivery and Tissue Repair View all 8 articles

Multiple applications of metal-organic frameworks(MOFs) in the treatment of orthopedic diseases

Provisionally accepted
Ziwen Zhao Ziwen Zhao 1Chengxu Wang Chengxu Wang 1AIGUO LIU AIGUO LIU 2Ning Bai Ning Bai 3Bo Jiang Bo Jiang 4Yuanfu Mao Yuanfu Mao 1Ting Ying Ting Ying 5,6Daming Dong Daming Dong 1Chengqing Yi Chengqing Yi 7Dejian Li Dejian Li 7*
  • 1 Department of Orthopedics,The First Affiliated Hospital of Harbin Medical University, Harbin Medical University, 157 Baojian road, Harbin, Heilongjiang Province, 150000, China, Harbin, China
  • 2 Department of Orthopedics, The First Affiliated Hospital of Henan University, Kaifeng, China, Henan, China
  • 3 Department of Gastroenterology, Huaihe Hospital, Henan University, Kaifeng, Henan Province, China
  • 4 Ningbo First Hospital, Ningbo, Zhejiang Province, China
  • 5 School of Medicine, Shanghai First Rehabilitation Hospital, Shanghai, Shanghai Municipality, China
  • 6 Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine,, Shanghai, China
  • 7 Department of Orthopaedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, 201399, P. R. China., Shanghai, China

The final, formatted version of the article will be published soon.

    Pharmacologic treatment of orthopedic diseases is a common challenge for clinical orthopedic surgeons, and as an important step in the stepwise treatment of orthopedic diseases, it is often difficult to achieve satisfactory results with existing pharmacologic treatments. Therefore, it is increasingly important to find new ways to effectively improve the treatment pattern of orthopedic diseases as well as to enhance the therapeutic efficacy. It has been found that metal-organic frameworks (MOFs) possess the advantages of high specific surface area, high porosity, chemical stability, tunability of structure and biocompatibility. Therefore, MOFs are expected to improve the conventional traditional treatment modality for bone diseases. This manuscript reviewed the applications of MOFs in the treatment of common clinical bone diseases and look forward to its future development.

    Keywords: Metal-Organic Frameworks, MOFs, tumor, Osteoporosis, Osteoarthritis

    Received: 12 Jun 2024; Accepted: 27 Aug 2024.

    Copyright: © 2024 Zhao, Wang, LIU, Bai, Jiang, Mao, Ying, Dong, Yi and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Dejian Li, Department of Orthopaedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, 201399, P. R. China., Shanghai, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.