Skip to main content

REVIEW article

Front. Bioeng. Biotechnol.
Sec. Nanobiotechnology
Volume 12 - 2024 | doi: 10.3389/fbioe.2024.1446355
This article is part of the Research Topic The Road toward Nano-Based Diagnostics for Health and Disease View all 4 articles

Recent advances in gold nanostructure-based biosensors in detecting diabetes biomarkers

Provisionally accepted
Tahereh Jamshidnejad-Tosaramandani Tahereh Jamshidnejad-Tosaramandani 1,2Soheila Kashanian Soheila Kashanian 2,3Kobra Omidfar Kobra Omidfar 4,5Helgi Schiöth Helgi Schiöth 1*
  • 1 Uppsala University, Uppsala, Sweden
  • 2 Faculty of Innovative Science and Technology, Razi University, Kermanshah, Kerman, Iran
  • 3 Faculty of Chemistry, Sensor, and Biosensor Research Centre, Razi University, Kermanshah, Kerman, Iran
  • 4 Endocrinology Research Center, Institute of Endocrinology and Metabolism Research and Training Center, Iran University of Medical Sciences, Tehran, Alborz, Iran
  • 5 Biosensor Research Center, Institute of Endocrinology and Metabolism, Tehran University of Medical Sciences, Tehran, Alborz, Iran

The final, formatted version of the article will be published soon.

    1. Au-NSs presented outstanding properties such as chemical stability, high electrical conductivity, a large specific surface area, low cost of synthesis, ease of functionalization.2. The utilization of Au-NSs in biosensors is an excellent opportunity in detecting all diabetes biomarkers such as glucose, HbA1c, GA insulin, IAA, and GADA.3. Au-NSs can improve the efficiency, sensitivity, specificity, and stability of the diabetes biosensors.4. The Au-NSs properties can increase the efficiency, sensitivity and specificity of the biosensor through intrinsic specific molecule recognition capacity, signal transduction amplification in different methods, fast electron transferring, the ability to stabilization of structures of GOx and/or antibodies over proper immobilization on electrodes, serving as fluorescent and colorimetric materials.5. Further consideration is required to translate Au-NSs-based technologies into routine and functional biosensors, as the properties of Au-NSs are dependent to their size, shape and spatial arrangement.

    Keywords: Diabetes Mellitus, , biosensor, , gold-nanostructures, biomarker, Glucose detection

    Received: 09 Jun 2024; Accepted: 08 Aug 2024.

    Copyright: © 2024 Jamshidnejad-Tosaramandani, Kashanian, Omidfar and Schiöth. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Helgi Schiöth, Uppsala University, Uppsala, Sweden

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.