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REVIEW article

Front. Bioeng. Biotechnol.
Sec. Nanobiotechnology
Volume 12 - 2024 | doi: 10.3389/fbioe.2024.1444201

Nanomedicines in diagnosis and treatment of prostate cancers: an updated review

Provisionally accepted
Jiajia Wang Jiajia Wang 1Xuan Zhang Xuan Zhang 2Jiazhen Xing Jiazhen Xing 2Lijian Gao Lijian Gao 2Hua Lu Hua Lu 2*
  • 1 Department of Oncology, Qilu Hospital of Shandong University Dezhou Hospital，Dezhou, 253000, China, Dezhou, China
  • 2 Department of Urology, Qilu Hospital of Shandong University Dezhou Hospital，Dezhou, 253000, China, Dezhou, China

The final, formatted version of the article will be published soon.

    Prostate cancer (PC) is the third most common male cancer in the world, which occurs due to various mutations leading to the loss of chromatin structure. There are multiple treatments for this type of cancer, of which chemotherapy is one of the most important. Sometimes, a combination of different treatments, such as chemotherapy, radiotherapy, and surgery, are used to prevent tumor recurrence. Among other treatments, androgen deprivation therapy (ADT) can be mentioned, which has had promising results. One of the drawbacks of chemotherapy and ADT treatments is that they are not targeted to the tumor tissue. For this reason, their use can cause extensive side effects. Treatments based on nanomaterials, known as nanomedicine, have attracted much attention today. Nanoparticles (NPs) are one of the main branches of nanomedicine, and they can be made of different materials such as polymer, metal, and carbon, each of which has distinct characteristics. In addition to NPs, nanovesicles (NVs) also have therapeutic applications in PC. In treating PC, synthetic NVs (liposomes, micelles, and nanobubbles) or produced from cells (exosomes) can be used. In addition to the role that NPs and NVs have in treating PC, due to being targeted, they can be used to diagnose PC and check the treatment process. Knowing the characteristics of nanomedicine-based treatments can help design new treatments and improve researchers' understanding of tumor biology and its rapid diagnosis. In this study, we will discuss conventional and nanomedicine-based treatments. The results of these studies show that the use of NPs and NVs in combination with conventional treatments has higher efficacy in tumor treatment than the individual use of each of them.

    Keywords: prostate cancer, Nanomedicine, exosome, diagnosis, Therapeutic application

    Received: 07 Jun 2024; Accepted: 05 Aug 2024.

    Copyright: © 2024 Wang, Zhang, Xing, Gao and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hua Lu, Department of Urology, Qilu Hospital of Shandong University Dezhou Hospital，Dezhou, 253000, China, Dezhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.