The final, formatted version of the article will be published soon.
REVIEW article
Front. Bioeng. Biotechnol.
Sec. Synthetic Biology
Volume 12 - 2024 |
doi: 10.3389/fbioe.2024.1437301
This article is part of the Research Topic Recent Advancements in RNA Technologies, Diagnostics, and Therapeutics View all articles
Engineering bacterial theranostics: from logic gates to in vivo applications
Provisionally accepted- Imperial College London, London, United Kingdom
Over the past two decades, rapid advances in synthetic biology have enabled the design of increasingly intricate and biologically relevant systems with broad applications in healthcare. A growing area of interest is in designing bacteria that sense and respond to endogenous diseaseassociated signals, creating engineered theranostics that function as disease surveyors for human health. In particular, engineered cells hold potential in facilitating greatly enhanced temporal and spatial control over the release of a range of therapeutics. Such systems are particularly useful for targeting challenging, under-drugged disease targets in a more nuanced manner than is currently possible. This review provides an overview of the recent advances in the design, delivery, and dynamics of bacterial theranostics to enable safe, robust, and genetically tractable therapies to treat disease. It outlines the primary challenges in theranostic clinical translation, proposes strategies to overcome these issues, and explores promising future avenues for the field.
Keywords: Synthetic Biology, theranostics, Prokaryotic, gene circuits, logic gates, gene networks, microbiome and dysbiosis, tumour microbiome
Received: 23 May 2024; Accepted: 05 Sep 2024.
Copyright: © 2024 Isalan and Armstrong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Mark Isalan, Imperial College London, London, United Kingdom
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.