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ORIGINAL RESEARCH article
Front. Bioeng. Biotechnol.
Sec. Biomaterials
Volume 12 - 2024 |
doi: 10.3389/fbioe.2024.1428988
This article is part of the Research Topic Advanced Functional Materials for Disease Diagnosis, Drug Delivery and Tissue Repair View all 7 articles
Antibacterial and antioxidant phlorizin-loaded nanofiber film effectively promotes the healing of burn wounds
Provisionally accepted
min Yang
1*
ying Yang
1*
Shuang Ma
2*
Ning A. Li
3*
feng G. Xia
3*
MIN li
1*
bo C. Ding
1,3*
fei X. Sun
3*
Li Yan
3*
Ting Zhao
1*- 1 Jilin Agricultural Science and Technology College, Jilin, China
- 2 Jilin Agriculture University, Changchun, Jilin Province, China
- 3 Jilin Aodong Yanbian Pharmaceutical Co, Ltd., YANBIAN, China
Burns usually result in damage and loss of skin forming irregular wound wounds.The lack of skin tissue protection makes the wound site highly vulnerable to bacterial infections, hindering the healing process. However, commonly used wound dressings do not readily provide complete coverage of irregular wounds compared to regular wounds. Therefore, there is an urgent need to prepare a wound dressing with high antimicrobial efficacy for the administration of drugs to irregular wounds. In this study, a chitosan (CS)/polyvinylpyrrolidone (PVP) composite nanofiber membrane (CS/PVP/Phlorizin) loaded with root bark glycosides (Phlorizin) was developed using an electrostatic spinning technique. The incorporation of phlorizin, a natural antioxidant, into the fiber membranes notably boosted their antimicrobial and antioxidant capabilities, along with demonstrating excellent hydrophilic characteristics. In vitro cellular experiments showed that CS/PVP/ Phlorizin increased Hacat cell viability with the presence of better cytocompatibility. In scald wound healing experiments, Phlorizin-loaded nanofibrous membranes significantly promoted re-epithelialization and angiogenesis at the wound site, and reduced the inflammatory response at the wound site. Therefore, the above results indicate that this nanofiber membrane is expected to be an ideal dressing for burn wounds.
Keywords: Chitosan, Phlorizin, Nanofiber membrane, Scalding Wound Repair, Wound Dressing
Received: 07 May 2024; Accepted: 19 Jul 2024.
Copyright: © 2024 Yang, Yang, Ma, Li, Xia, li, Ding, Sun, Yan and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
min Yang, Jilin Agricultural Science and Technology College, Jilin, China
ying Yang, Jilin Agricultural Science and Technology College, Jilin, China
Shuang Ma, Jilin Agriculture University, Changchun, 130118, Jilin Province, China
Ning A. Li, Jilin Aodong Yanbian Pharmaceutical Co, Ltd., YANBIAN, China
feng G. Xia, Jilin Aodong Yanbian Pharmaceutical Co, Ltd., YANBIAN, China
MIN li, Jilin Agricultural Science and Technology College, Jilin, China
bo C. Ding, Jilin Agricultural Science and Technology College, Jilin, China
fei X. Sun, Jilin Aodong Yanbian Pharmaceutical Co, Ltd., YANBIAN, China
Li Yan, Jilin Aodong Yanbian Pharmaceutical Co, Ltd., YANBIAN, China
Ting Zhao, Jilin Agricultural Science and Technology College, Jilin, China
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