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REVIEW article

Front. Bioeng. Biotechnol.
Sec. Tissue Engineering and Regenerative Medicine
Volume 12 - 2024 | doi: 10.3389/fbioe.2024.1428793

Therapeutic application of mesenchymal stem cell-derived exosomes in skin wound healing

Provisionally accepted
Yunhan Sun Yunhan Sun 1*Shun Zhang Shun Zhang 1Yukai Shen Yukai Shen 1Haoyang Lu Haoyang Lu 1*Xincan Zhao Xincan Zhao 1Xin Wang Xin Wang 1*Yongkai Wang Yongkai Wang 1*Taiping Wang Taiping Wang 1*Bing Liu Bing Liu 1*Lan Yao Lan Yao 2*Jie Wen Jie Wen 1*
  • 1 School of Stomatology, Shandong First Medical University, Jinan, China
  • 2 Eye Hospital of Shandong First Medical University, Jinan, China

The final, formatted version of the article will be published soon.

    Wound healing is a complicated obstacle, especially for chronic wounds.Mesenchymal stem cell-derived exosomes may be a promising cell-free approach for treating skin wound healing. Exosomes can accelerate wound healing by attenuating inflammation, promoting angiogenesis, cell proliferation, extracellular matrix production and remodeling. However, many issues, such as off-target effects and high degradation of exosomes in wound sites need to be addressed before applying into clinical therapy. Therefore, the bioengineering technology has been introduced to modify exosomes with greater stability and specific therapeutic property. To prolong the function time and the local concentration of exosomes in the wound bed, the use of biomaterials to load exosomes emerges as a promising strategy. In this review, we summarize the biogenesis and characteristics of exosomes, the role of exosomes in wound healing, and the therapeutic applications of modified-exosomes in wound healing. The challenges and prospects of exosomes in wound healing are also discussed.

    Keywords: Skin wound healing, exosoems, bioengeneering, Hydrogel, nanofiber

    Received: 08 May 2024; Accepted: 25 Jul 2024.

    Copyright: © 2024 Sun, Zhang, Shen, Lu, Zhao, Wang, Wang, Wang, Liu, Yao and Wen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yunhan Sun, School of Stomatology, Shandong First Medical University, Jinan, China
    Haoyang Lu, School of Stomatology, Shandong First Medical University, Jinan, China
    Xin Wang, School of Stomatology, Shandong First Medical University, Jinan, China
    Yongkai Wang, School of Stomatology, Shandong First Medical University, Jinan, China
    Taiping Wang, School of Stomatology, Shandong First Medical University, Jinan, China
    Bing Liu, School of Stomatology, Shandong First Medical University, Jinan, China
    Lan Yao, Eye Hospital of Shandong First Medical University, Jinan, China
    Jie Wen, School of Stomatology, Shandong First Medical University, Jinan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.