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REVIEW article

Front. Bioeng. Biotechnol.
Sec. Synthetic Biology
Volume 12 - 2024 | doi: 10.3389/fbioe.2024.1427248

Promising non-model microbial cell factories obtained by genome reduction

Provisionally accepted
Giulia Ravagnan Giulia Ravagnan Jochen Schmid Jochen Schmid *
  • Biology, University of Münster, Münster, Germany

The final, formatted version of the article will be published soon.

    The development of sustainable processes is the most important basis to realize the shift from the fossil-fuel based industry to bio-based production. Non-model microbes represent a great resource due to their advantageous traits and unique repertoire of bioproducts. However, most of these microbes require modifications to improve their growth and production capacities as well as robustness in terms of genetic stability. For this, genome reduction is a valuable and powerful approach to meet industry requirements and to design highly efficient production strains. Here, we provide an overview of various genome reduction approaches in prokaryotic microorganisms, with a focus on non-model organisms, and highlight the example of a successful genome-reduced model organism chassis. Furthermore, we discuss the advances and challenges of promising non-model microbial chassis.

    Keywords: Genome Reduction, chassis, Genetic Engineering, non-model microbes, Bacteria

    Received: 03 May 2024; Accepted: 12 Jun 2024.

    Copyright: © 2024 Ravagnan and Schmid. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jochen Schmid, Biology, University of Münster, Münster, Germany

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.