Skip to main content

REVIEW article

Front. Bioeng. Biotechnol.
Sec. Tissue Engineering and Regenerative Medicine
Volume 12 - 2024 | doi: 10.3389/fbioe.2024.1421674

Revolutionizing Bone Defect Healing: The Power of Mesenchymal Stem Cells as Seeds

Provisionally accepted
Yueyao Zhang Yueyao Zhang 1,2,3Mengke Fan Mengke Fan 1,2,3Yingze Zhang Yingze Zhang 1,2,3*
  • 1 Third Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
  • 2 Other, Shijiazhuang, Hebei Province, China
  • 3 Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei Province, China

The final, formatted version of the article will be published soon.

    Bone defects can arise from trauma or pathological factors, resulting in compromised bone integrity and the loss or absence of bone tissue. As we are all aware, repairing bone defects is a core problem in bone tissue engineering. While minor bone defects can self-repair if the periosteum remains intact and normal osteogenesis occurs, significant defects or conditions such as congenital osteogenesis imperfecta present substantial challenges to self-healing. As research on mesenchymal stem cell (MSC) advances, new fields of application have emerged; however, their application in orthopedics remains one of the most established and clinically valuable directions. This review aims to provide a comprehensive overview of the research progress regarding MSCs in the treatment of diverse bone defects. MSCs, as multipotent stem cells, offer significant advantages due to their immunomodulatory properties and ability to undergo osteogenic differentiation. The review will encompass the characteristics of MSCs within the osteogenic microenvironment and summarize the research progress of MSCs in different types of bone defects, ranging from their fundamental characteristics and animal studies to clinical applications.

    Keywords: Mesenchymal Stem Cells, Bone defect, Bone microenvironment, biomaterial, bone tissue engineering

    Received: 22 Apr 2024; Accepted: 10 Oct 2024.

    Copyright: © 2024 Zhang, Fan and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yingze Zhang, Third Hospital of Hebei Medical University, Shijiazhuang, 050051, Hebei Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.