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REVIEW article

Front. Bioeng. Biotechnol.
Sec. Tissue Engineering and Regenerative Medicine
Volume 12 - 2024 | doi: 10.3389/fbioe.2024.1417440
This article is part of the Research Topic Biomechanical and Biomaterial Advances in Degenerative Diseases of Bone and Joint View all articles

Finite element analysis and in vitro tests on endurance life and durability of composite bone substitutes

Provisionally accepted
Amir Abbas Seraji Amir Abbas Seraji 1Reza Nahavandi Reza Nahavandi 2*Amir Kia Amir Kia 3Ahad Rabbani Doost Ahad Rabbani Doost 4Vahid Keshavarz Vahid Keshavarz 5Fariborz Sharifianjazi Fariborz Sharifianjazi 6Ketevan Tavamaishvili Ketevan Tavamaishvili 7Dorna Makarem Dorna Makarem 8
  • 1 University of Toronto, Toronto, Ontario, Canada
  • 2 University of Tehran, Tehran, Iran
  • 3 University of Guilan, Rasht, Gilan, Iran
  • 4 Iran Polymer and Petrochemical Institute, Tehran, Tehran, Iran
  • 5 Imam Khomeini International University, Qazvin, Qazvin, Iran
  • 6 University of Georgia, Tbilisi, Georgia
  • 7 Georgian American University, Tbilisi, Georgia
  • 8 Centro Láser, Universidad Politécnica de Madrid, Madrid, Asturias, Spain

The final, formatted version of the article will be published soon.

    Bone structures facilitate the regeneration and repair of bone tissue in regions where it has been damaged or destroyed, either temporarily or permanently. Therefore, the bone's fatigue strength and durability are crucial to its efficacy and longevity. Several variables, such as the construct's material qualities, design, and production procedure, loading and unloading cycles, and physiological conditions influence the endurance life of bone constructs. Metals, ceramics, and polymers are all routinely utilized to create bone substitutes, and each of these materials has unique features that might affect the fatigue strength and endurance life of the final product.The mechanical performance and capacity to promote bone tissue regeneration may be affected by the scaffold's design, porosity, and pore size.Researchers employ mechanical testing under cyclic loading circumstances as one example of an experimental approach used to assess bone construction endurance. These analyses can give us important information about the stress-strain behavior, resistance to multiple loading cycles, and fatigue strength of the new structure. Predicting the endurance life of the developed construct may also be possible with the use of simulations and numerical analyses. Hence, in order to create reliable and efficient constructs for bone tissue engineering, it is crucial to understand their fatigue strength and durability. The purpose of this study is to analyze the effective parameters for fatigue strength of bone structures and to gather the models and evaluations utilized in endurance life assessments.

    Keywords: Endurance life, durability, cyclic loading, bone constructs, Fatigue strength, bone tissue engineering

    Received: 14 Apr 2024; Accepted: 27 Aug 2024.

    Copyright: © 2024 Seraji, Nahavandi, Kia, Rabbani Doost, Keshavarz, Sharifianjazi, Tavamaishvili and Makarem. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Reza Nahavandi, University of Tehran, Tehran, Iran

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.