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ORIGINAL RESEARCH article

Front. Bioeng. Biotechnol.
Sec. Biomaterials
Volume 12 - 2024 | doi: 10.3389/fbioe.2024.1406336
This article is part of the Research Topic Functional Biomaterials for Drug Delivery View all 6 articles

Release of natural extracts from PVA and PVA-CMC hydrogel wound dressings: a Power law swelling/delivery

Provisionally accepted
Renata Nunes Oliveira Renata Nunes Oliveira 1*Luiz A. da Cruz Meleiro Luiz A. da Cruz Meleiro 1Brid Quilty Brid Quilty 2Garrett B. McGuinness Garrett B. McGuinness 2
  • 1 Federal Rural University of Rio de Janeiro, Seropédica, Brazil
  • 2 Dublin City University, Dublin, County Dublin, Ireland

The final, formatted version of the article will be published soon.

    The present work aims to study the physical, mechanical and release characteristics of hydrogel wound dressings loaded with either of two natural herbal products. PVA matrices incorporating sage extract or dragon's blood (DB) present hydrogen bonding between these components. PVA-CMC hydrogels containing sage present similar spectra to PVA-CMC alone, probably indicating low miscibility or interaction between the matrix and sage. The opposite is found for DB, which exhibits more pronounced interference with crystallinity than sage. DB and NaCMC negatively affect Young's modulus and failure strength. All samples appear to reach equilibrium swelling degree (ESD) in 24h. The addition of DB and sage to PVA increases the gels' swelling capacity, indicating that the substances likely separate PVA chains. The inclusion of CMC contributes to high media uptake. The kinetics profile of media uptake for 4 days is described by a power-law model, which is correlated to the drug delivery mechanism. A PVA-CMC gel incorporating 15% DB, the highest amount tested, shows the most favorable characteristics for flavonoid delivery, as well as flexibility and swelling capacity.

    Keywords: Dragon's blood, sage extract, PVA, Hydrogel, Wound Dressing

    Received: 24 Mar 2024; Accepted: 05 Jul 2024.

    Copyright: © 2024 Nunes Oliveira, da Cruz Meleiro, Quilty and McGuinness. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Renata Nunes Oliveira, Federal Rural University of Rio de Janeiro, Seropédica, Brazil

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.