AUTHOR=Lin Fanzhen , Li Wenwei , Wang Dan , Hu Ge , Qin Zhao , Xia Xue , Hu Lin , Liu Xuemei , Luo Ruoshi 

TITLE=Advances in succinic acid production: the enhancement of CO2 fixation for the carbon sequestration benefits

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=12

YEAR=2024

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2024.1392414

DOI=10.3389/fbioe.2024.1392414

ISSN=2296-4185

ABSTRACT=<p>Succinic acid (SA), one of the 12 top platform chemicals produced from biomass, is a precursor of various high value-added derivatives. Specially, 1 mol CO<sub>2</sub> is assimilated in 1 mol SA biosynthetic route under anaerobic conditions, which helps to achieve carbon reduction goals. In this review, methods for enhanced CO<sub>2</sub> fixation in SA production and utilization of waste biomass for SA production are reviewed. Bioelectrochemical and bioreactor coupling systems constructed with off-gas reutilization to capture CO<sub>2</sub> more efficiently were highlighted. In addition, the techno-economic analysis and carbon sequestration benefits for the synthesis of bio-based SA from CO<sub>2</sub> and waste biomass are analyzed. Finally, a droplet microfluidics-based high-throughput screening technique applied to the future bioproduction of SA is proposed as a promising approach.</p>