AUTHOR=Lin Lin , Chen Lin , Yan Juan , Chen Peirong , Du Jiahui , Zhu Junpeng , Yang Xinyu , Geng Boxin , Li Lang , Zeng Wen TITLE=Advances of nanoparticle-mediated diagnostic and theranostic strategies for atherosclerosis JOURNAL=Frontiers in Bioengineering and Biotechnology VOLUME=11 YEAR=2023 URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2023.1268428 DOI=10.3389/fbioe.2023.1268428 ISSN=2296-4185 ABSTRACT=

Atherosclerotic plaque remains the primary cause of morbidity and mortality worldwide. Accurate assessment of the degree of atherosclerotic plaque is critical for predicting the risk of atherosclerotic plaque and monitoring the results after intervention. Compared with traditional technology, the imaging technologies of nanoparticles have distinct advantages and great development prospects in the identification and characterization of vulnerable atherosclerotic plaque. Here, we systematically summarize the latest advances of targeted nanoparticle approaches in the diagnosis of atherosclerotic plaque, including multimodal imaging, fluorescence imaging, photoacoustic imaging, exosome diagnosis, and highlighted the theranostic progress as a new therapeutic strategy. Finally, we discuss the major challenges that need to be addressed for future development and clinical transformation.