AUTHOR=Liang Xinqiang , Xu Wenting , Li Siyi , Kurboniyon Mekhrdod S. , Huang Kunying , Xu Guilan , Wei Wene , Ning Shufang , Zhang Litu , Wang Chen 

TITLE=Tailoring mSiO2-SmCox nanoplatforms for magnetic/photothermal effect-induced hyperthermia therapy

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=11

YEAR=2023

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2023.1249775

DOI=10.3389/fbioe.2023.1249775

ISSN=2296-4185

ABSTRACT=<p>Hyperthermia therapy is a hotspot because of its minimally invasive treatment process and strong targeting effect. Herein, a synergistic magnetic and photothermal therapeutic nanoplatform is rationally constructed. The well-dispersive mSiO<sub>2</sub>-SmCo<sub>x</sub> nanoparticles (NPs) were synthesized through a one-step procedure with the regulated theoretical molar ratio of Sm/Co among 1:1, 1:2, and 1:4 for controlling the dispersion and magnetism properties of SmCo<sub>x</sub> NPs <italic>in situ</italic> growth in the pore structure of mesoporous SiO<sub>2</sub> (mSiO<sub>2</sub>), where mSiO<sub>2</sub> with diverse porous structures and high specific surface areas serving for locating the permanent magnetic SmCo<sub>x</sub> NPs. The mSiO<sub>2</sub>-SmCo<sub>x</sub> (Sm/Co = 1:2) NPs with highly dispersed and uniform morphology has an average diameter of ∼73.08 nm. The photothermal conversion efficiency of mSiO<sub>2</sub>-SmCo<sub>x</sub> (Sm/Co = 1:2) NPs was determined to be nearly 41%. The further <italic>in vitro</italic> and <italic>in vivo</italic> anti-tumor evaluation of mSiO<sub>2</sub>-SmCo<sub>x</sub> (Sm/Co = 1:2) NPs present promising potentials for hyperthermia-induced tumor therapy due to magnetic and photothermal effects.</p>