AUTHOR=Jennissen Herbert P. 

TITLE=Camouflaged angiogenic BMP-2 functions exposed by pico-paracrine biohybrids

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=11

YEAR=2023

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2023.1226649

DOI=10.3389/fbioe.2023.1226649

ISSN=2296-4185

ABSTRACT=<p>The constant release of human bone morphogenetic protein 2 (rhBMP-2) in the picomolar range (Pico-Stat) from PDLLA-biohybrids led to the detection of intrinsic novel pro- and anti-angiogenic functions of this cytokine. As integrant part in this perspective of previous work, first evidence for the binding of rhBMP-2, as an <italic>inverse agonist</italic>, to allosteric angiogenic receptors in cocultures of human endothelial cells is reported.</p>