AUTHOR=Zhao Lingzhu , Zhao Guoqing , Feng Jinteng , Zhang Zheng , Zhang Jiayu , Guo Hui , Lin Min TITLE=T Cell engineering for cancer immunotherapy by manipulating mechanosensitive force-bearing receptors JOURNAL=Frontiers in Bioengineering and Biotechnology VOLUME=11 YEAR=2023 URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2023.1220074 DOI=10.3389/fbioe.2023.1220074 ISSN=2296-4185 ABSTRACT=

T cell immune responses are critical for in both physiological and pathological processes. While biochemical cues are important, mechanical cues arising from the microenvironment have also been found to act a significant role in regulating various T cell immune responses, including activation, cytokine production, metabolism, proliferation, and migration. The immune synapse contains force-sensitive receptors that convert these mechanical cues into biochemical signals. This phenomenon is accepted in the emerging research field of immunomechanobiology. In this review, we provide insights into immunomechanobiology, with a specific focus on how mechanosensitive receptors are bound and triggered, and ultimately resulting T cell immune responses.