AUTHOR=Lin Ping-Yuan , Chung Yi-Wei , Chuang Er-Yuan , Wang Yen-Chieh , Lai Min-Chih , Hsu Yen-Chin , Lin Chun-Che , Hsiao Yu-Cheng 

TITLE=Cholesteric liquid crystal biosensor platform with image analysis for rapid detection of COVID-19

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=11

YEAR=2023

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2023.1148446

DOI=10.3389/fbioe.2023.1148446

ISSN=2296-4185

ABSTRACT=<p>Rapid and low-cost diagnosis of coronavirus disease 2019 (COVID-19) is essential to identify infected subjects, particularly asymptomatic cases, primarily to arrest the spread of the disease through local transmission. Antibody-based chromatographic serological tests, as an alternative to the RT-PCR technique, offer only limited help due to high false positives. We propose to exploit our cholesteric liquid crystal biosensor platform for one-step, wash-free, rapid detection of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus directly with minimal sample pre-processing. As mentioned above, cholesteric liquid crystals are an effective and innovative approach to healthcare as a rapid test for the diagnosis of COVID-19 and other diseases.</p>