AUTHOR=Hernandez Andrea , Hartgerink Jeffrey D. , Young Simon 

TITLE=Self-assembling peptides as immunomodulatory biomaterials

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=Volume 11 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2023.1139782

DOI=10.3389/fbioe.2023.1139782

ISSN=2296-4185

ABSTRACT=Self-assembling peptides are a type of biomaterial rapidly emerging in the fields of biomedicine and 10 material sciences due to their promise in biocompatibility and effectiveness at controlled release. 11 These self-assembling peptides can form diverse nanostructures in response to molecular 12 interactions, making them versatile materials. Once assembled, the peptides can mimic biological 13 functions and provide a combinatorial delivery of therapeutics such as cytokines and drugs. These 14 self-assembling peptides are showing success in biomedical settings yet face unique challenges that 15 must be addressed to be widely applied in the clinic. Herein, we describe self-assembling peptides' 16 characteristics and current applications in immunomodulatory therapeutics.