AUTHOR=Jiang Yunsheng , Li Tao , Yang Junjun , Wang Xin , Song Xiongbo , Chen Guangxing , Dai Gang , Li Rong , Yao Chunyan , Chen Jiajia , Chen Cheng , Gong Xiaoyuan , Yang Liu 

TITLE=Sustained intra-articular reactive oxygen species scavenging and alleviation of osteoarthritis by biocompatible amino-modified tantalum nanoparticles

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=11

YEAR=2023

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2023.1118850

DOI=10.3389/fbioe.2023.1118850

ISSN=2296-4185

ABSTRACT=<p>Recent studies highlight the vital role of oxidative stress and reactive oxygen species (ROS) during progression of osteoarthritis (OA). Attenuating oxidative stress and reducing reactive oxygen species generation in joints represent reasonable strategies for the treatment of osteoarthritis. To address the potential question for clinical translation, and improve the biocompatibility and long-term performance of current antioxidants, the present study provided high biocompatible small positively charged tantalum nanoparticles (Ta-NH<sub>2</sub> NPs) with sustained intra-articular catalase activity and first applied to osteoarthritis intervention. Our <italic>in vitro</italic> results showed that Ta-NH<sub>2</sub> NPs were stable with good biocompatibility, and protected viability and hyaline-like phenotype in H<sub>2</sub>O<sub>2</sub>-challenged chondrocytes. In addition, the <italic>in vivo</italic> biodistribution data demonstrated a sustained retention of Ta-NH<sub>2</sub> NPs in the joint cavity, particularly in articular cartilage without organ toxicity and abnormality in hemogram or blood biochemistry indexes. Finally, compared with catalase (CAT), Ta-NH<sub>2</sub> NPs exhibited long-term therapeutic effect in monosodium iodoacetate (MIA) induced osteoarthritis model. This study preliminarily explored the potential of simply modified metal nanoparticles as effective reactive oxygen species scavenging agent for osteoarthritis intervention, and offered a novel strategy to achieve sustained reactive oxygen species suppression using biocompatible Ta-based nano-medicine in oxidative stress related diseases.</p>