AUTHOR=Lin Wensheng , Lin Shixian , Zhou Xingwu , Yang Fanwen , Lin Zishan , Li Shiqing , Zhang Haoyuan , Ouyang Yuehan , Zhu Jieying , Sun Wei , Huang Dequn , Liao Baojian , Zhu Jixiang TITLE=Biodegradable double-network GelMA-ACNM hydrogel microneedles for transdermal drug delivery JOURNAL=Frontiers in Bioengineering and Biotechnology VOLUME=11 YEAR=2023 URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2023.1110604 DOI=10.3389/fbioe.2023.1110604 ISSN=2296-4185 ABSTRACT=

As a minimally invasive drug delivery platform, microneedles (MNs) overcome many drawbacks of the conventional transdermal drug delivery systems, therefore are favorable in biomedical applications. Microneedles with a combined burst and sustained release profile and maintained therapeutic molecular bioactivity could further broaden its applications as therapeutics. Here, we developed a double-network microneedles (DN MNs) based on gelatin methacrylate and acellular neural matrix (GelMA-ACNM). ACNM could function as an early drug release matrix, whereas the addition of GelMA facilitates sustained drug release. In particular, the double-network microneedles comprising GelMA-ACNM hydrogel has distinctive biological features in maintaining drug activity to meet the needs of application in treating different diseases. In this study, we prepared the double-network microneedles and evaluated its morphology, mechanical properties, drug release properties and biocompatibility, which shows great potential for delivery of therapeutic molecules that needs different release profiles in transdermal treatment.