AUTHOR=Peng Chen , He Wei , Huang Xingsheng , Ma Jun , Yuan Tong , Shi Yun , Wang Shengzhang
TITLE=The study on the impact of AAA wall motion on the hemodynamics based on 4D CT image data
JOURNAL=Frontiers in Bioengineering and Biotechnology
VOLUME=11
YEAR=2023
URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2023.1103905
DOI=10.3389/fbioe.2023.1103905
ISSN=2296-4185
ABSTRACT=Purpose: To analyze the effect of the physiological deformation of the vessel wall on the hemodynamics in the abdominal aortic aneurysm (AAA), this paper compared the hemodynamics in AAA based on the moving boundary (MB) simulation and the rigid wall (RW) simulation.
Method: Patient-specific models were reconstructed to generate mesh based on four-dimensional computed tomography angiography (4D CT) data. The dynamic mesh technique was used to achieve deformation of the vessel wall, surface mesh and volume mesh of the fluid domain were successively remeshed at each time step. Besides, another rigid wall simulation was performed. Hemodynamics obtained from these two simulations were compared.
Results: Flow field and wall shear stress (WSS) distribution are similar. When using the moving boundary method (MBM), mean time-averaged wall shear stress (TAWSS) is lower, mean oscillatory shear index (OSI) and mean relative residence time (RRT) are higher. When using the 10th and 20th percentile values for TAWSS and 80th and 90th percentile values for RRT, the ratios of areas with low TAWSS, high OSI and high RRT to the entire vessel wall are higher than those assuming the vessel as rigid. In addition, one overlapping region of low TAWSS, high OSI and high RRT by using the MBM is consistent with the location of thrombus obtained from the follow-up imaging data.
Conclusion: The hemodynamics results by using the MBM reflect a higher blood retention effect. This paper presents a potential tool to assess the risk of intraluminal thrombus (ILT) formation based on the MBM.