AUTHOR=Dubey Astita , Salamon Soma , Attanayake Supun B. , Ibrahim Syaidah , Landers Joachim , Castillo Marianela Escobar , Wende Heiko , Srikanth Hari , Shvartsman Vladimir V. , Lupascu Doru C. 

TITLE=Rare-earth doped BiFe0.95Mn0.05O3 nanoparticles for potential hyperthermia applications

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2022.965146

DOI=10.3389/fbioe.2022.965146

ISSN=2296-4185

ABSTRACT=<p>Ionic engineering is exploited to substitute Bi cations in BiFe<sub>0.95</sub>Mn<sub>0.05</sub>O<sub>3</sub> NPs (BFM) with rare-earth (RE) elements (Nd, Gd, and Dy). The sol-gel synthesized RE-NPs are tested for their magnetic hyperthermia potential. RE-dopants alter the morphology of BFM NPs from elliptical to rectangular to irregular hexagonal for Nd, Gd, and Dy doping, respectively. The RE-BFM NPs are ferroelectric and show larger piezoresponse than the pristine BFO NPs. There is an increase of the maximum magnetization at 300 K of BFM up to 550% by introducing Gd. In hyperthermia tests, 3 mg/ml dispersion of NPs in water and agar could increase the temperature of the dispersion up to ∼39°C under an applied AC magnetic field of 80 mT. Although Gd doping generates the highest increment in magnetization of BFM NPs, the Dy-BFM NPs show the best hyperthermia results. These findings show that RE-doped BFO NPs are promising for hyperthermia and other biomedical applications.</p>