AUTHOR=Pozzobon Michela , D’Agostino Stefania , Roubelakis Maria G. , Cargnoni Anna , Gramignoli Roberto , Wolbank Susanne , Gindraux Florelle , Bollini Sveva , Kerdjoudj Halima , Fenelon Mathilde , Di Pietro Roberta , Basile Mariangela , Borutinskaitė Veronika , Piva Roberta , Schoeberlein Andreina , Eissner Guenther , Giebel Bernd , Ponsaerts Peter TITLE=General consensus on multimodal functions and validation analysis of perinatal derivatives for regenerative medicine applications JOURNAL=Frontiers in Bioengineering and Biotechnology VOLUME=10 YEAR=2022 URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2022.961987 DOI=10.3389/fbioe.2022.961987 ISSN=2296-4185 ABSTRACT=

Perinatal tissues, such as placenta and umbilical cord contain a variety of somatic stem cell types, spanning from the largely used hematopoietic stem and progenitor cells to the most recently described broadly multipotent epithelial and stromal cells. As perinatal derivatives (PnD), several of these cell types and related products provide an interesting regenerative potential for a variety of diseases. Within COST SPRINT Action, we continue our review series, revising and summarizing the modalities of action and proposed medical approaches using PnD products: cells, secretome, extracellular vesicles, and decellularized tissues. Focusing on the brain, bone, skeletal muscle, heart, intestinal, liver, and lung pathologies, we discuss the importance of potency testing in validating PnD therapeutics, and critically evaluate the concept of PnD application in the field of tissue regeneration. Hereby we aim to shed light on the actual therapeutic properties of PnD, with an open eye for future clinical application. This review is part of a quadrinomial series on functional/potency assays for validation of PnD, spanning biological functions, such as immunomodulation, anti-microbial/anti-cancer, anti-inflammation, wound healing, angiogenesis, and regeneration.