AUTHOR=Dong Chen , Ma Xuehua , Huang Yi , Zhang Yujie , Gao Xiang 

TITLE=Carbon dots nanozyme for anti-inflammatory therapy via scavenging intracellular reactive oxygen species

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2022.943399

DOI=10.3389/fbioe.2022.943399

ISSN=2296-4185

ABSTRACT=<p>Developing an efficient antioxidant for anti-inflammatory therapy <italic>via</italic> scavenging reactive oxygen species (ROS) remains a great challenge owing to the insufficient activity and stability of traditional antioxidants. Herein, we explored and simply synthesized a biocompatible carbon dots (CDs) nanozyme with excellent scavenging activity of ROS for anti-inflammatory therapy. As expected, CDs nanozyme effectively eliminate many kinds of free radicals including <sup>•</sup>OH, O<sub>2</sub><sup>•<bold>−</bold></sup>, and ABTS<sup>+</sup>•. Benefiting from multienzyme activities against ROS, CDs nanozyme can decrease the levels of pro-inflammatory cytokines, resulting in good anti-inflammatory effect. Taken together, this study not only sheds light on design of bioactive antioxidants but also broadens the biomedical application of CDs in the treatment of inflammation.</p>