AUTHOR=kang Binbin , Lan Dongmei , Yao Chao , Liu Ping , Chen Xiaohong , Qi Shengcai 

TITLE=Evaluation of antibacterial property and biocompatibility of Cu doped TiO2 coated implant prepared by micro-arc oxidation

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2022.941109

DOI=10.3389/fbioe.2022.941109

ISSN=2296-4185

ABSTRACT=<p>In order to enhance osteogenic differentiation and antibacterial property of dental implants, volcano-shaped microporous TiO<sub>2</sub> coatings doped with Cu were fabricated via micro-arc oxidation (MAO) on Ti. Cu-doped coating with different mass ratios of Cu were obtained by changing the concentration of copper acetate in the electrolyte. The structure of Cu-TiO<sub>2</sub> coatings were systematically investigated. Element Copper was uniformly distributed throughout the coating. Compared with TiO<sub>2</sub> coating, the Cu-doped can further improved proliferation of bone mesenchymal stem cells (BMSCs), facilitated osteogenic differentiation. The bacteriostasis experiments demonstrated that Cu-doped TiO<sub>2</sub> coating possess excellent antibacterial property against <italic>Staphylococcus aureus</italic> (<italic>S. aureus</italic>) and Porphyromonas gingivalis (<italic>P. gingivalis</italic>).</p>