AUTHOR=MacAdam Aidan , Chaudry Emaan , McTiernan Christopher D. , Cortes David , Suuronen Erik J. , Alarcon Emilio I. 

TITLE=Development of in situ bioprinting: A mini review

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2022.940896

DOI=10.3389/fbioe.2022.940896

ISSN=2296-4185

ABSTRACT=<p>Bioprinting has rapidly progressed over the past decade. One branch of bioprinting known as <italic>in situ</italic> bioprinting has benefitted considerably from innovations in biofabrication. Unlike <italic>ex situ</italic> bioprinting, <italic>in situ</italic> bioprinting allows for biomaterials to be printed directly into or onto the target tissue/organ, eliminating the need to transfer pre-made three-dimensional constructs. In this mini-review, recent progress on <italic>in situ</italic> bioprinting, including bioink composition, <italic>in situ</italic> crosslinking strategies, and bioprinter functionality are examined. Future directions of <italic>in situ</italic> bioprinting are also discussed including the use of minimally invasive bioprinters to print tissues within the body.</p>