AUTHOR=Aliberti Flaminia , Paolin Elisa , Benedetti Laura , Cusella Gabriella , Ceccarelli Gabriele TITLE=3D bioprinting and Rigenera® micrografting technology: A possible countermeasure for wound healing in spaceflight JOURNAL=Frontiers in Bioengineering and Biotechnology VOLUME=10 YEAR=2022 URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2022.937709 DOI=10.3389/fbioe.2022.937709 ISSN=2296-4185 ABSTRACT=

Plant and animal life forms have progressively developed mechanisms for perceiving and responding to gravity on Earth, where homeostatic mechanisms require feedback. Lack of gravity, as in the International Space Station (ISS), induces acute intra-generational changes in the quality of life. These include reduced bone calcium levels and muscle tone, provoking skin deterioration. All these problems reduce the work efficiency and quality of life of humans not only during exposure to microgravity (µG) but also after returning to Earth. This article discusses forthcoming experiments required under gravity and µG conditions to ensure effective and successful medical treatments for astronauts during long-term space missions, where healthcare is difficult and not guaranteed.