Jia Luo
XueXin Lin
LiLing Li
JingQian Tan
Peng Li
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- 1Department of Otolaryngology Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
- 2Department of Otolaryngology Head and Neck Surgery, The Eighth Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China
A Corrigendum on
β-Cyclodextrin and Oligoarginine Peptide-Based Dendrimer-Entrapped Gold Nanoparticles for ImprovingDrug Delivery to the Inner Ear
Drug Delivery to the Inner Earby Luo, J., Lin, X., Li, L., Tan, J., and Li, P. (2022). Front. Bioeng. Biotechnol. 10:844177. doi: 10.3389/fbioe.2022.844177
In the original article, there was a mistake in Figure 9E, panel d as published. Figure 9E has been redrawn and the corrected Figure 9E appears below.
FIGURE 9
FIGURE 9. (A) Rapid changes in the CAP threshold of mice recorded from the facial nerve after treatment with streptomycin alone, streptomycin mixed with Dex, and streptomycin mixed with Au-DENPs-Dex (Au@CD-PAMAM-Arg8/Dex). (B) Comparison of hearing improvement among each group in response to 1, 2, 3, 4, 6, 8, 16, and 32 kHz; *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001. The damage of nerve endings below the inner hair cells (C), spiral ganglion cells (D), and OHCs and IHCs (E) with different treatment methods under confocal microscopy.
In the original article, there was an error in section two, Experimental Section, whereby several descriptions for the preparation of nanocomposites CD-PAMAM-Arg8 and CD-PAMAM-Arg8/Dex were omitted.
The following correction should be made to Experimental Section, “2.2.3 Preparation of Nanocomposites With Drugs”, paragraph 1:
“Arg8 polypeptides (lipid concentration: 1.5 mg/ml), EDC (lipid concentration: 0.2 mg/ml), and NHS (lipid concentration: 0.4 mg/ml) were added into PBS (pH = 7.4) and stirred at room temperature for 4 h. The drug-loaded nanomaterial powder (Au @CD-PAMAM) was dissolved in PBS, and then the commixture of the two solutions was obtained and allowed to react overnight at room temperature. The mixture was freeze-dried to obtain the drug-loaded nanocomposite material with targeted properties of Au @CD-PAMAM-Arg8(Au-DENPs). The free chemical residues were removed by dialysis using a 1-kDa MWCO membrane. Dexamethasone (Dex) dissolved in DMSO (concentration: 2 mg/ml) was added to the Au-DENPs. The mixed solution was stirred overnight at room temperature, filtrated with a 2-kDa MWCO membrane and freeze-dried to get Au @CD-PAMAM-Arg8/Dex (Au DENPs-Dex).”
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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Keywords: drug delivery, dexamethasone, inner ear, spiral ganglion, outer hair cells, nerve fibers
Citation: Luo J, Lin X, Li L, Tan J and Li P (2022) Corrigendum: β-Cyclodextrin and Oligoarginine Peptide-Based Dendrimer-Entrapped Gold Nanoparticles for Improving Drug Delivery to the Inner Ear. Front. Bioeng. Biotechnol. 10:921652. doi: 10.3389/fbioe.2022.921652
Received: 16 April 2022; Accepted: 03 May 2022;
Published: 23 May 2022.
Edited and reviewed by:
Kaili Lin, Shanghai Jiao Tong University, ChinaCopyright © 2022 Luo, Lin, Li, Tan and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Peng Li, bHA3NkAxNjMubmV0